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How to Administer Weight Loss Injections – Dosing & Injection Guide | Slim Shots UK
Semaglutide Tirzepatide Retatrutide Melanotan 2

How to Administer Weight Loss Injections

Complete Dosing, Reconstitution & Injection Technique Guide

Always consult a healthcare professional before starting any injection protocol.

Select Your Compound for a Full Guide

What You'll Need

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Supplies

  • Your peptide vial
  • Bacteriostatic water (BAC water)
  • U-100 insulin syringes
  • Alcohol swabs (x2 per injection)
  • Sharps disposal bin
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Syringe Guide

  • Type: U-100 insulin syringe
  • Gauge: 29–31G (finer = less pain)
  • Needle length: 4–8mm
  • Capacity: 0.3ml or 1ml barrel
  • 100 units = 1.0ml on a U-100 syringe
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Storage Rules

  • Unmixed vial: cool, dark place
  • Mixed vial: fridge at 2–8°C
  • Use within: 28 days of mixing
  • Never freeze a mixed vial
  • Discard if cloudy or discoloured

How to Reconstitute (Mix) Your Vial

Follow these steps every time you mix a new vial

1

Wash your hands thoroughly

Use soap and water for at least 20 seconds. Dry with a clean towel before handling any equipment.

2

Swab both vial tops

Use a fresh alcohol swab on the rubber stopper of your peptide vial and your BAC water vial. Allow to air-dry for 10 seconds — do not blow on them.

3

Draw the correct volume of BAC water

Insert your syringe into the BAC water vial and pull back the plunger to draw the exact volume specified for your compound (e.g. 1.0ml for Tirzepatide, 2.0ml for a Semaglutide 5mg vial).

4

Inject water slowly down the side of the vial

Insert the needle into the peptide vial at an angle so the water runs down the glass wall — not directly onto the powder. This prevents foaming and degradation.

Never shake the vial. Gently swirl or roll between your palms until fully dissolved.
5

Inspect the solution

The reconstituted solution should be clear and colourless. If it appears cloudy, has particles, or is discoloured — do not use it.

6

Label and refrigerate immediately

Write the date of mixing on the vial. Store in the fridge at 2–8°C. Use within 28 days.

Subcutaneous Injection Technique

All weight loss compounds covered here are administered subcutaneously (under the skin)

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Abdomen

2 inches either side of the navel. Most common site — easy to pinch and inject.

Recommended
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Outer Thigh

Middle outer section of the thigh. Good alternative if abdomen is sore.

Good Alternative
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Upper Arm

Back of the upper arm. Easier with assistance. Rotate with other sites.

With Assistance

Step-by-Step Injection

1
Draw your dose — Insert the syringe into the mixed vial and pull back to the exact unit/ml marking for your dose. Check for air bubbles and flick them out.
2
Swab the injection site — Clean the skin with an alcohol swab and allow to air-dry for 10 seconds.
3
Pinch the skin — Use your thumb and forefinger to gently pinch a fold of skin at the injection site.
4
Insert at 45–90° — For thinner individuals use 45°; for more body fat use 90°. Insert the full needle length in one smooth motion.
5
Inject slowly — Push the plunger down steadily over 5–10 seconds. Do not rush.
6
Withdraw and release — Pull the needle out at the same angle it went in. Release the skin fold.
7
Apply gentle pressure — Press a clean swab over the site for a few seconds. Do not rub — this can cause bruising.
8
Dispose safely — Place the used syringe immediately into your sharps bin. Never recap needles.
Rotate injection sites every week. Using the same spot repeatedly causes lipohypertrophy (lumpy scar tissue) which reduces absorption.

Frequently Asked Questions

Bacteriostatic water is sterile water containing 0.9% benzyl alcohol, which prevents bacterial growth. It is the correct diluent for reconstituting peptide vials and allows the mixed solution to be stored safely in the fridge for up to 28 days. Do not use plain sterile water — it has no preservative and the solution must be used immediately.
Use a U-100 insulin syringe. For weight loss compounds (Semaglutide, Tirzepatide, Retatrutide), a 1ml barrel is ideal. For Melanotan 2 micro-doses, use a 0.3ml syringe for greater accuracy. Needle gauge: 29–31G, length 4–8mm.
If you miss a weekly dose and it has been fewer than 5 days since your scheduled injection, take it as soon as you remember. If it has been 5 or more days, skip the missed dose and resume your normal weekly schedule. Never take two doses in the same week.
Once reconstituted with bacteriostatic water, vials should be stored in the fridge at 2–8°C and used within 28 days. Always label the vial with the date of mixing. Discard any unused solution after 28 days.
Nausea is the most common side effect, especially in the first 2–4 weeks. Tips: inject in the evening so you sleep through the worst of it; eat smaller, low-fat meals; avoid spicy or greasy food on injection day; stay well hydrated; ginger tea or anti-nausea tablets can help. If nausea is severe, hold your current dose for an extra 4 weeks before stepping up.
Full compound profiles, clinical data, and dosing information are available at slimshots.info. Our expert team is also available via WhatsApp 7 days a week for guidance on dosing, storage, and protocol questions.

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Always consult a healthcare professional before starting any injection protocol.